Angiogenesis in liver disease

JOURNAL OF HEPATOLOGY

卷:50

Review

Fernandez, Mercedes^1,2  Semela, David³  Bruix, Jordi^2,4  Colle, Isabelle⁵  Pinzani, Massimo⁶  Bosch, Jaume^1,2 

[1] Univ Barcelona, Liver Unit, Hepat Hemodynam Lab, Hosp Clin IDIBAPS, E-08036 Barcelona, Spain

[2] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona, Spain

[3] Univ Basel Hosp, Div Gastroenterol & Hepatol, CH-4031 Basel, Switzerland

[4] Univ Barcelona, Liver Unit, Barcelona Clin Liver Canc BCLC Grp, Hosp Clin IDIBAPS, E-08036 Barcelona, Spain

[5] Ghent Univ Hosp, Dept Gastroenterol & Hepatol, B-9000 Ghent, Belgium

[6] Univ Florence, Dipartimento Med Interna, Ctr Res High Educ & Transfer DENOThe, Florence, Italy

关键词: Angiogenesis;    Liver fibrosis;    Portal hypertension;    Liver cancer;    Liver regeneration;   

DOI  :  10.1016/j.jhep.2008.12.011

来源: Elsevier

【 摘 要 】

Angiogenesis and disruption of liver vascular architecture have been linked to progression to cirrhosis and liver cancer (HCC) in chronic liver diseases, which contributes both to increased hepatic vascular resistance and portal hypertension and to decreased hepatocyte perfusion. On the other hand, recent evidence shows that angiogenesis modulates the formation of portal-systemic collaterals and the increased splanchnic blood flow which are involved in the life threatening complications of cirrhosis. Finally, angiogenesis plays a key role in the growth of tumours, suggesting that interference with angiogenesis may prevent or delay the development of HCC. This review summarizes current knowledge on the molecular mechanisms of liver angiogenesis and on the consequences of angiogenesis in chronic liver disease. On the other hand, it presents the different strategies that have been used in experimental models to counteract excessive angiogenesis and its potential role in preventing transition to cirrhosis, development of portal hypertension and its consequences, and its application in the treatment of hepatocellular carcinoma. (C) 2009 Published by Elsevier B.V. on behalf of the European Association for the Study of the Liver.

【 授权许可】

Free