Impact of microenvironment and stem-like plasticity in cholangiocarcinoma: Molecular networks and biological concepts

JOURNAL OF HEPATOLOGY

卷:62

Review

Raggi, Chiara^1,2  Invernizzi, Pietro^1,2  Andersen, Jesper B.³ 

[1] Humanitas Clin & Res Ctr, Liver Unit, I-20089 Rozzano, MI, Italy

[2] Humanitas Clin & Res Ctr, Ctr Autoimmune Liver Dis, I-20089 Rozzano, MI, Italy

[3] Univ Copenhagen, Biotech Res & Innovat Ctr, Copenhagen, Denmark

关键词: Cholangiocarcinoma;    Cancer stem cells;    Tumour microenvironment;    Tumour associated macrophages;   

DOI  :  10.1016/j.jhep.2014.09.007

来源: Elsevier

【 摘 要 】

Clinical complexity, anatomic diversity and molecular heterogeneity of cholangiocarcinoma (CCA) represent a major challenge in the assessment of effective targeted therapies. Molecular and cellular mechanisms underlying the diversity of CCA growth patterns remain a key issue of clinical concern. Crucial questions comprise the nature of the CCA-origin, the initial target for cellular transformation as well as the relationship with the cancer stem cells (CSC) concept. Additionally, since CCA often develops in the context of an inflammatory milieu (cirrhosis and cholangitis), the stromal compartment or tumour microenvironment (TME) likely promotes initiation and progression of this malignancy, contributing to its heterogeneity. This review will emphasize the dynamic interplay between stem-like intrinsic and TME-extrinsic pathways, which may represent novel options for multi-targeted therapies in CCA. (C) 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

【 授权许可】

Free