Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies

JOURNAL OF HEPATOLOGY

卷:46

Review

Hemmann, Stefanie ; Graf, Juergen ; Roderfeld, Martin ; Roeb, Elke

关键词: liver;    fibrosis;    MMP;    TIMP;    matrix;    metalloproteinase;    tissue;    inhibitor;    therapy;    expression;   

DOI  :  10.1016/j.jhep.2007.02.003

来源: Elsevier

【 摘 要 】

In liver tissue matrix metalloproteinases (MMPs) and their specific inhibitors (tissue inhibitors of metalloproteinases, TIMPs) play a pivotal role in both, fibrogenesis and fibrolysis. The current knowledge of the pathophysiology of liver fibrogenesis with special emphasis on MMPs and TIMPs is presented. A systematic literature search was conducted. All experimental models of liver fibrosis that evaluated a defined anti-fibrotic intervention in vivo or in vitro considering MMPs and TIMPs were selected. The methodological quality of all these publications has been critically appraised using an objective scoring system and the content has been summarized in a table. (C) 2007 European Association for the Study of the Liver. Published by Elsevier BN. All rights reserved.

【 授权许可】

Free