期刊论文详细信息
JOURNAL OF HEPATOLOGY 卷:42
Hepatitis B virus X protein promotes cell migration by inducing matrix metalloproteinase-3
Article
Yu, FL ; Liu, HJ ; Lee, JW ; Liao, MH ; Shih, WL
关键词: hepatitis B virus;    HBV X protein;    hepatocellular carcinoma;    matrix metalloproteinase-3;    cDNA microarray;   
DOI  :  10.1016/j.jhep.2004.11.031
来源: Elsevier
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【 摘 要 】

Background/Aims: Hepatitis B virus (HBV), a major causative agent of hepatocellular carcinoma (HCC), encodes an oncogenic X protein (HBx) that transcriptionally activates multiple viral and cellular promoters. How this regulation influences HCC is unclear. Methods: Global gene expression in HBx-expressing and non-expressing hepatoma cells was analyzed using cDNA microarrays. Results: Genes that were markedly up- or down-regulated in the presence of HBx included those involved in signal transduction, metabolism, apoptosis, cytokine production, cell cycle, cell adhesion and oncogenesis. Other genes of ill-defined function were also affected. Trans-activation proficient HBx up-regulated the transcription, translation and secretion of matrix metalloproteinase-3 (MMP-3), manifest as a cell migratory phenotype. This HBx effect was abrogated in the presence of a MMP-3 specific peptide inhibitor. Conclusions: HBx exerts selective transcriptional control in hepatoma cells and induces cellular migration through the activation of MMP-3. (C) 2004 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

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