Acute-on chronic liver failure

JOURNAL OF HEPATOLOGY

卷:57

Review

Jalan, Rajiv¹  Gines, Pere^2,3  Olson, Jody C.⁴  Mookerjee, Rajeshwar P.¹  Moreau, Richard^5,6  Garcia-Tsao, Guadalupe⁷  Arroyo, Vicente^2,3  Kamath, Patrick S.⁴ 

[1] Royal Free Hosp, UCL Med Sch, UCL Inst Liver & Digest Hlth, Liver Failure Grp, London NW3 2PF, England

[2] Univ Barcelona, Hosp Clin Barcelona, Liver Unit, Barcelona, Catalunya, Spain

[3] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Inst Invest Biomed August Pi Sunyer IDIBAPS, Madrid, Spain

[4] Mayo Clin, Coll Med, Div Gastroenterol & Hepatol, Rochester, MN USA

[5] Ctr Rech Biomed Bichat Beaujon CRB3, U773, INSERM, Paris, France

[6] Ctr Rech Biomed Bichat Beaujon CRB3, U773, INSERM, Clichy, France

[7] Yale Univ, Sch Med, Sect Digest Dis, New Haven, CT USA

关键词: Acute-on chronic liver failure;    Hepatorenal syndrome;    Hepatic encephalopathy;    Immune failure;    Liver support;    Liver transplantation;   

DOI  :  10.1016/j.jhep.2012.06.026

来源: Elsevier

【 摘 要 】

Acute-on-chronic liver failure (ACLF) is an increasingly recognised entity encompassing an acute deterioration of liver function in patients with cirrhosis, which is usually associated with a precipitating event and results in the failure of one or more organs and high short term mortality. Prospective data to define this is lacking but there is a large body of circumstantial evidence suggesting that this condition is a distinct clinical entity. From the pathophysiologic perspective, altered host response to injury and infection play important roles in its development. This review focuses upon the current understanding of this syndrome from the clinical, prognostic and pathophysiologic perspectives and indicates potential biomarkers and therapeutic targets for intervention. (C) 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

【 授权许可】

Free