Advances in functional and molecular MRI technologies in chronic liver diseases

JOURNAL OF HEPATOLOGY

卷:73

Review

Zhou, Iris Y.^1,2,3  Catalano, Onofrio A.^1,2,4  Caravan, Peter^1,2,3 

[1] Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA

[2] Harvard Med Sch, Boston, MA 02115 USA

[3] Massachusetts Gen Hosp, Inst Innovat Imaging I3, Dept Radiol, Charlestown, MA USA

[4] Massachusetts Gen Hosp, Dept Radiol, Div Abdominal Imaging, Boston, MA USA

关键词: Perfusion imaging;    Hepatocyte function;    Functional imaging;    Molecular imaging;    MRI;    Chronic liver diseases;    Fibrosis;    Contrast agents;   

DOI  :  10.1016/j.jhep.2020.06.020

来源: Elsevier

【 摘 要 】

MRI has emerged as the most comprehensive non-invasive diagnostic tool for liver diseases. In recent years, the value of MRI in hepatology has been significantly enhanced by a wide range of contrast agents, both clinically available and under development, that add functional information to anatomically detailed morphological images, or increase the distinction between normal and pathological tissues by targeting molecular and cellular events. Several classes of contrast agents are available for contrastenhanced hepatic MRI, including i) conventional non-specific extracellular fluid contrast agents for assessing tissue perfusion; ii) hepatobiliary-specific contrast agents that are taken up by functioning hepatocytes and excreted through the biliary system for evaluating hepatobiliary function; iii) superparamagnetic iron oxide particles that accumulate in Kupffer cells; and iv) novel molecular contrast agents that are biochemically targeted to specific molecular/cellular processes for staging liver diseases or detecting treatment responses. The use of different functional and molecular MRI methods enables the non-invasive assessment of disease burden, progression, and treatment response in a variety of liver diseases. A high diagnostic performance can be achieved with MRI by combining imaging biomarkers. (C) 2020 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

【 授权许可】

Free