HCV reinfection incidence and spontaneous clearance rates in HIV-positive men who have sex with men in Western Europe

JOURNAL OF HEPATOLOGY

卷:66

Article

Ingiliz, Patrick¹  Martin, Thomas C.²  Rodger, Alison³  Stellbrink, Hans-Juergen⁴  Mauss, Stefan⁵  Boesecke, Christoph⁶  Mandorfer, Mattias⁷  Bottero, Julie⁸  Baumgarten, Axel¹  Bhagani, Sanjay³  Lacombe, Karine^8,9  Nelson, Mark^2,10 

[1] Ctr Infectiol CIB, Seestr 13, Berlin, Germany

[2] Chelsea & Westminster Hosp, London, England

[3] Royal Free Hosp, London, England

[4] ICH, Hamburg, Germany

[5] Ctr HIV & Hepatogastroenterol, Dusseldorf, Germany

[6] Univ Bonn, Dept Med 1, Bonn, Germany

[7] Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, Vienna, Austria

[8] Hop St Antoine, AP HP, Serv Malad Infect & Trop, Paris, France

[9] UPMC Univ Paris 06, Sorbonne Univ, INSERM, IPLESP,UMRS 1136, Paris, France

[10] Imperial Coll Sch Med, London, England

关键词: HCV reinfection;    Acute hepatitis C;    HIV-HCV coinfection;    SVR;    Spontaneous clearance;    HCV therapy;   

DOI  :  10.1016/j.jhep.2016.09.004

来源: Elsevier

【 摘 要 】

Background & Aims: Moderate cure rates of acute hepatitis C virus (HCV) infections with pegylated interferon and ribavirin have been described in the last decade in men who have sex with men (MSM), who are also coinfected with the human immunodeficiency virus (HIV). However, a subsequent high incidence of HCV reinfections has been reported regionally in men who both clear the infection spontaneously or who respond to treatment. Methods: Retrospective analysis of reinfections in HIV infected MSM in eight centers from Austria, France, Germany, and the UK within the NEAT network between May 2002 and June 2014. Results: Of 606 individuals who cleared HCV spontaneously or were successfully treated, 149 (24.6%) presented with a subsequent HCV reinfection. Thirty out of 70 (43%) who cleared again or were successfully treated, presented with a second reinfection, 5 with a third, and one with a fourth reinfection. The reinfection incidence was 7.3/100 person-years (95% CI 6.2-8.6). We found a trend for lower incidence among individuals who had spontaneously cleared their incident infection than among individuals who were treated (Hazard ratio 0.62, 95% CI 0.38-1.02, p = 0.06). Spontaneous clearance of reinfection was associated with ALT levels >1000 IU/ml and spontaneous clearance of a prior infection. Conclusions: HCV reinfection is an issue of major concern in HIV positive MSM. Prevention strategies are needed for high risk groups to reduce morbidity and treatment costs. HIV-positive MSM with a prior HCV infection should be tested every 3 to 6 months for reinfection. Those who had achieved a reinfection should be tested every 3 months. Lay summary: We evaluated the occurrence of HCV reinfection in HIV-positive men who have sex with men. We found an alarming incidence of 7.3/100 person-years. Prevention measures need to address this specific subgroup of patients at high risk for HCV. (C) 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

【 授权许可】

Free