Danger signals in liver injury and restoration of homeostasis

JOURNAL OF HEPATOLOGY

卷:73

Review

Han, Hui¹  Desert, Romain¹  Das, Sukanta¹  Song, Zhuolun¹  Athavale, Dipti¹  Ge, Xiaodong¹  Nieto, Natalia^1,2 

[1] Univ Illinois, Dept Pathol, 840 S Wood St,Suite 130 CSN,MC 847, Chicago, IL 60612 USA

[2] Univ Illinois, Dept Med, Div Gastroenterol & Hepatol, 840 S Wood St,Suite 1020N,MC 787, Chicago, IL 60612 USA

关键词: Alcohol-related liver disease;    Hepatocellular carcinoma;    Liver fibrosis;    Liver transplantation;    Non-alcoholic steatohepatitis;    Oxidative stress;   

DOI  :  10.1016/j.jhep.2020.04.033

来源: Elsevier

【 摘 要 】

Damage-associated molecular patterns are signalling molecules involved in inflammatory responses and restoration of homeostasis. Chronic release of these molecules can also promote inflammation in the context of liver disease. Herein, we provide a comprehensive summary of the role of damage-associated molecular patterns as danger signals in liver injury. We consider the role of reactive oxygen species and reactive nitrogen species as inducers of damage-associated molecular patterns, as well as how specific damage-associated molecular patterns participate in the pathogenesis of chronic liver diseases such as alcohol-related liver disease, non-alcoholic steatohepatitis, liver fibrosis and liver cancer. In addition, we discuss the role of damage-associated molecular patterns in ischaemia reperfusion injury and liver transplantation and highlight current studies in which blockade of specific damage-associated molecular patterns has proven beneficial in humans and mice. (C) 2020 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

【 授权许可】

Free