Assessment of human exposure to triclocarban, triclosan and five parabens in US indoor dust using dispersive solid phase extraction followed by liquid chromatography tandem mass spectrometry

JOURNAL OF HAZARDOUS MATERIALS

卷:360

Article

Chen, Jing¹  Hartmann, Erica M.²  Kline, Jeff³  Van den Wymelenberg, Kevin³  Halden, Rolf U.¹ 

[1] Arizona State Univ, Biodesign Ctr Environm Hlth Engn, Biodesign Inst, Sch Sustainable Engn & Built Environm, 781 E Terrace Mall, Tempe, AZ 85287 USA

[2] Northwestern Univ, Dept Civil & Environm Engn, 2145 Sheridan Rd, Evanston, IL 60208 USA

[3] Univ Oregon, Coll Design, Biol & Built Environm Ctr, Eugene, OR 97403 USA

关键词: Dust;    Paraben;    Triclosan;    Triclocarban;    QuEChERS;   

DOI  :  10.1016/j.jhazmat.2018.08.014

来源: Elsevier

【 摘 要 】

Antimicrobials in indoor dust pose concerns due to their endocrine disrupting activities and potential promotion of antibiotic resistance. We adopted dispersive solid phase extraction (d-SPE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to quantify antimicrobials in dust. The method showed favorable linearity (R-2 > 0.99), recovery (83-115%), and method detection limits (1.2-5.6 ng/g, dry weight). All seven analytes were found at median concentrations in ng/g in each of the 80 U.S. dust samples collected from athletic facilities and residential homes: methyl paraben (1920) > propyl paraben (965) > triclosan (390) > triclocarban (270) > ethyl paraben (195) > butyl paraben (80) > benzyl paraben (6). Triclosan levels in dust from athletic facilities were significantly higher than those in private homes (p < 0.05). Median estimated daily intake (EDI) of antimicrobials in ng/kg-body weight/d from dust ingestion was lowest for adults (1.9) and higher for more sensitive subpopulations, including infants (19.8), toddlers (23.6), children (11.8) and teenagers (4.6). This first application of d-SPE to the analysis of dust produced U.S. baseline data for triclosan and triclocarban levels in indoor dust just prior to the 2017 Federal ban on use of these trichlorinated aromatics in antiseptic soaps and related personal care products.

【 授权许可】

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