Tetrabromobisphenol A induced reproductive endocrine-disrupting effects in mussel Mytilus galloprovincialis

JOURNAL OF HAZARDOUS MATERIALS

卷:416

Article

Wang, Shuang¹  Ji, Chenglong^1,2,3  Li, Fei^1,3  Zhan, Junfei^1,4  Sun, Tao^1,4  Tang, Jianhui^1,3  Wu, Huifeng^1,2,3 

[1] Chinese Acad Sci, Shandong Key Lab Coastal Environm Processes, CAS Key Lab Coastal Environm Processes & Ecol Rem, Yantai Inst Coastal Zone Res,YICCAS, Yantai 264003, Peoples R China

[2] Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China

[3] Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 26071, Peoples R China

[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

关键词: Brominated flame retardants;    Marine invertebrates;    Endocrine disruptor;    Steroids sulfonation;   

DOI  :  10.1016/j.jhazmat.2021.126228

来源: Elsevier

【 摘 要 】

Tetrabromobisphenol A (TBBPA) pollution in marine environmental media poses great risks to marine organisms due to its potential endocrine-disrupting effects. However, limited attention of TBBPA's endocrine-disrupting effects has been paid on marine invertebrates. In this work, the reproductive endocrine-disrupting effects of TBBPA were evaluated by observing the gametes development, quantifying the gender-specific gene expression, and determining vertebrate sex hormones in mussels Mytilus galloprovincialis treated with TBBPA for 30 days. Additionally, transcriptomic profiling and enzymes activities were conducted to investigate the potential mechanisms of reproductive endocrine-disrupting effects. We found that promotion of gametogenesis and alterations of vertebrate sex hormones occurred in TBBPA-treated mussels of both sexes. Meanwhile, estrogen sulfotransferase (SULT1E1) and steroid sulfatase (STS) were up-regulated at transcript level as a result of TBBPA treatments, suggesting that TBBPA disrupted the steroidogenesis in mussels through promoting steroids sulfo-nation and hydrolysis of sulfate steroids. The induction of SULTs for TBBPA biotransformation might be responsible for the dysregulation of steroidogenesis and steroids metabolism. Overall, these findings provide a new insight into assessing impact of TBBPA as well as TBBPA biomonitoring in marine environment.

【 授权许可】

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