Degradation of silica particles functionalised with essential oil components under simulated physiological conditions

JOURNAL OF HAZARDOUS MATERIALS

卷:399

Article

Fuentes, Cristina¹  Ruiz-Rico, Maria¹  Fuentes, Ana¹  Jose Ruiz, Maria²  Manuel Barat, Jose¹ 

[1] Univ Politecn Valencia, Dept Food Technol, Camino Vera S-N, Valencia 46022, Spain

[2] Univ Valencia, Fac Pharm, Lab Toxicol, Av Vicent Andres Estelles S-N, Valencia 46100, Spain

关键词: Silica;    MCM-41;    Functionalisation;    In vitro digestion;    Artificial lysosomal fluid;   

DOI  :  10.1016/j.jhazmat.2020.123120

来源: Elsevier

【 摘 要 】

In this work, the biodurability of three silica particle types (synthetic amourphous silica, MCM-41 microparticles, MCM-41 nanoparticles) functionalised with three different essential oil components (carvacrol, eugenol, vanillin) was studied under conditions that represented the human gastrointestinal tract and lysosomal fluid. The effect of particle type, surface immobilised component and mass quantity on the physico-chemical properties of particles and silicon dissolution was determined. Exposure to biological fluids did not bring about changes in the zeta potential values or particle size distribution of the bare or functionalised materials, but the in vitro digestion process partially degraded the structure of the MCM-41 nanoparticles. Functionalisation preserved the structure of the MCM-41 nanoparticles after simulating an in vitro digestion process, and significantly decreased the amount of silicon dissolved after exposing different particles to both physiological conditions, independently of the essential oil component anchored to their surface. The MCM-41 microparticles showed the highest solubility, while synthetic amorphous silica presented the lowest levels of dissolved silicon. The study of these modified silica particles under physiological conditions could help to predict the toxicological behaviour of these new materials.

【 授权许可】

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