Sertraline accumulation and effects in the estuarine decapod Carcinus maenas: Importance of the history of exposure to chemical stress

JOURNAL OF HAZARDOUS MATERIALS

卷:283

Article

Rodrigues, Aurelie P.^1,2  Santos, Lucia H. M. L. M.³  Ramalhosa, Maria Joao³  Delerue-Matos, Cristina³  Guimaraes, Laura¹ 

[1] Univ Porto, Interdisciplinary Ctr Marine & Environm Res CIIMA, P-4050123 Oporto, Portugal

[2] Univ Porto, ICBAS Inst Biomed Sci Abel Salazar, P-4050313 Oporto, Portugal

[3] Inst Politecn Porto, Inst Super Engn Porto, REQUIMTE, P-4200072 Oporto, Portugal

关键词: Bioaccumulation;    Cholinergic neurotransmission;    Oxidative stress;    Exposure history;    Risk assessment;    Invertebrates;   

DOI  :  10.1016/j.jhazmat.2014.08.035

来源: Elsevier

【 摘 要 】

Sertraline is widely prescribed worldwide and frequently detected in aquatic systems. There is, however, a remarkable gap of information on its potential impact on estuarine and coastal invertebrates. This study investigated sertraline accumulation and effects in Carcinus maenas. Crabs from a moderately contaminated (Lima) and a low-impacted (Minho) estuary were exposed to environmental and high levels of sertraline (0.05, 5, 500 mu g L-1). A battery of biomarkers related to sertraline mode of action was employed to assess neurotransmission, energy metabolism, biotransformation and oxidative stress pathways. After a seven-day exposure, sertraline accumulation in crabs' soft tissues was found in Lima (5 mu g L-1:15.3 ng L-1 ww; 500 mu g L-1: 1010 ng L-1 ww) and Minho (500 mu g L-1: 605 ng L-1 ww) animals. Lima crabs were also more sensitive to sertraline than those from Minho, exhibiting decreased acetylcholinesterase activity, indicative of ventilatory and locomotory dysfunction, inhibition of antioxidant enzymes and increased oxidative damage at >= 0.05 mu g L-1. The Integrated Biomarker Response (IBR) index indicated their low health status. In addition, Minho crabs showed non-monotonic responses of acetylcholinesterase suggestive of hormesis. The results pointed an influence of the exposure history on differential sensitivity to sertraline and the need to perform evaluations with site-specific ecological receptors to increase relevance of risk estimations when extrapolating from laboratory to field conditions. (C) 2014 Elsevier B.V. All rights reserved.

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