Activation and Evasion of Innate Immunity by Gammaherpesviruses

JOURNAL OF MOLECULAR BIOLOGY

卷:434

Review

Damania, Blossom¹ 

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27515 USA

关键词: KSHV;    EBV;    MHV68;    gammaherpesvirus;    innate immunity;   

DOI  :  10.1016/j.jmb.2021.167214

来源: Elsevier

【 摘 要 】

Gammaherpesviruses are ubiquitous pathogens that establish lifelong infections in the vast majority of adults worldwide. Importantly, these viruses are associated with numerous malignancies and are respon-sible for significant human cancer burden. These virus-associated cancers are due, in part, to the ability of gammaherpesviruses to successfully evade the innate immune response throughout the course of infec-tion. In this review, we will summarize the current understanding of how gammaherpesviruses are detected by innate immune sensors, how these viruses evade recognition by host cells, and how this knowledge can inform novel therapeutic approaches for these viruses and their associated diseases. (c) 2021 Elsevier Ltd. All rights reserved.

【 授权许可】

Free