Quality Control in Neurons: Mitophagy and Other Selective Autophagy Mechanisms

JOURNAL OF MOLECULAR BIOLOGY

卷:432

Review

Evans, Chantell S.¹  Holzbaur, Erika L. F.¹ 

[1] Univ Penn, Perelman Sch Med, Dept Physiol, 638A Clinical Res Bldg,415 Curie Blvd, Philadelphia, PA 19104 USA

关键词: selective autophagy;    mitophagy;    neurodegeneration;    mitochondrial quality control;    ER-phagy;   

DOI  :  10.1016/j.jmb.2019.06.031

来源: Elsevier

【 摘 要 】

The cargo-specific removal of organelles via selective autophagy is important to maintain neuronal homeostasis. Genetic studies indicate that deficits in these pathways are implicated in neurodegenerative diseases, including Parkinson's and amyotrophic lateral sclerosis. Here, we review our current understanding of the pathways that regulate mitochondrial quality control, and compare these mechanisms to those regulating turnover of the endoplasmic reticulum and the clearance of protein aggregates. Research suggests that there are multiple mechanisms regulating the degradation of specific cargos, such as dysfunctional organelles and protein aggregates. These mechanisms are critical for neuronal health, as neurons are uniquely vulnerable to impairment in organelle quality control pathways due to their morphology, size, polarity, and postmitotic nature. We highlight the consequences of dysregulation of selective autophagy in neurons and discuss current challenges in correlating noncongruent findings from in vitro and in vivo systems. (C) 2019 Elsevier Ltd. All rights reserved.

【 授权许可】

Free