O-GIcNAcylation in Cancer Biology: Linking Metabolism and Signaling

JOURNAL OF MOLECULAR BIOLOGY

卷:428

Review

Ferrer, Christina M.¹  Sodi, Valerie L.¹  Reginato, Mauricio J.¹ 

[1] Drexel Univ, Coll Med, Dept Biochem & Mol Biol, Philadelphia, PA 19102 USA

关键词: glycosylation;    signaling;    cancer;    O-GIcNAcylation;    OGT;   

DOI  :  10.1016/j.jmb.2016.05.028

来源: Elsevier

【 摘 要 】

The hexosamine biosynthetic pathway (HBP) is highly dependent on multiple metabolic nutrients including glucose, glutamine, and acetyl-CoA. Increased flux through HBP leads to elevated post-translational addition of beta-D-N-acetylglucosamine sugars to nuclear and cytoplasmic proteins. Increased total O-GIcNAcylation is emerging as a general characteristic of cancer cells, and recent studies suggest that O-GIcNAcylation is a central communicator of nutritional status to control key signaling and metabolic pathways that regulate multiple cancer cell phenotypes. This review summarizes our current understanding of changes of O-GIcNAc cycling enzymes in cancer, the role of O-GIcNAcylation in tumorigenesis, and the current challenges in targeting this pathway therapeutically. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free