RNA Sequence Features Are at the Core of Influenza A Virus Genome Packaging

JOURNAL OF MOLECULAR BIOLOGY

卷:431

Review

Shafiuddin, Md¹  Boon, Adrianus C. M.^1,2,3 

[1] Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Mol Microbiol & Microbial Pathogenesis, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

关键词: influenza virus;    genome packaging;    reassortment;   

DOI  :  10.1016/j.jmb.2019.03.018

来源: Elsevier

【 摘 要 】

The influenza A virus (IAV), a respiratory pathogen for humans, poses serious medical and economic challenges to global healthcare systems. The IAV genome, consisting of eight single-stranded viral RNA segments, is incorporated into virions by a complex process known as genome packaging. Specific RNA sequences within the viral RNA segments serve as signals that are necessary for genome packaging. Although efficient packaging is a prerequisite for viral infectivity, many of the mechanistic details about this process are still missing. In this review, we discuss the recent advances toward the understanding of IAV genome packaging and focus on the RNA features that play a role in this process. (C) 2019 Elsevier Ltd. All rights reserved.

【 授权许可】

Free