The Role of Functional Amyloids in Bacterial Virulence

JOURNAL OF MOLECULAR BIOLOGY

卷:430

Review

Remaut, Han¹ 

[1] Vrije Univ Brussel, Struct Biol Brussels, Pl Laan 2, B-1050 Brussels, Belgium

关键词: biofilm;    bacterial adhesion;    bacterial pathogenesis;    curli;    amyloid;   

DOI  :  10.1016/j.jmb.2018.07.010

来源: Elsevier

【 摘 要 】

Amyloid fibrils are best known as a product of human and animal protein misfolding disorders, where amyloid formation is associated with cytotoxicity and disease. It is now evident that for some proteins, the amyloid state constitutes the native structure and serves a functional role. These functional amyloids are proving widespread in bacteria and fungi, fulfilling diverse functions as structural components in biofilms or spore coats, as toxins and surface-active fibers, as epigenetic material, peptide reservoirs or adhesins mediating binding to and internalization into host cells. In this review, we will focus on the role of functional amyloids in bacterial pathogenesis. The role of functional amyloids as virulence factor is diverse but mostly indirect. Nevertheless, functional amyloid pathways deserve consideration for the acute and long-term effects of the infectious disease process and may form valid antimicrobial targets. (C) 2018 The Authors. Published by Elsevier Ltd.

【 授权许可】

Free