Unorthodox Mechanisms to Initiate Translation Open Novel Paths for Gene Expression

JOURNAL OF MOLECULAR BIOLOGY

卷:432

Review

Hernandez, Greco¹  Garcia, Alejandra¹  Sonenberg, Nahum^2,3  Lasko, Paul^4,5 

[1] Natl Inst Canc, Translat & Canc Lab, Unit Biomed Res Canc, 22 San Fernando Ave, Mexico City 14080, DF, Mexico

[2] McGill Univ, Dept Biochem, Montreal, PQ H3A 1A3, Canada

[3] McGill Univ, Goodman Canc Ctr, Montreal, PQ H3A 1A3, Canada

[4] McGill Univ, Dept Biol, Montreal, PQ, Canada

[5] Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Nijmegen, Netherlands

关键词: eIF4G;    eIF4E;    eIF3;    mextli;    CERES;    48S;    translation initiation;    translational control;   

DOI  :  10.1016/j.jmb.2020.10.035

来源: Elsevier

【 摘 要 】

Translation in eukaryotes is dependent on the activity of translation initiation factor (eIF) 4G family of proteins, a scaffold protein that, during the initiation step, coordinates the activity of other eIFs to recruit the 40S ribosomal subunit to the mRNA. Three decades of research on protein synthesis and its regulation has provided a wealth of evidence supporting the crucial role of cap-dependent translation initiation, which involves eIF4G. However, the recent discovery of a surprising variety of alternative mechanisms to initiate translation in the absence of eIF4G has stirred the orthodox view of how protein synthesis is performed. These mechanisms involve novel interactions among known eIFs, or between known eIFs and other proteins not previously linked to translation. Thus, a new picture is emerging in which the unorthodox translation initiation complexes contribute to the diversity of mechanisms that regulate gene expression in eukaryotes. (C) 2020 Elsevier Ltd. All rights reserved.

【 授权许可】

Free