Functional Amyloid and Other Protein Fibers in the Biofilm Matrix

JOURNAL OF MOLECULAR BIOLOGY

卷:430

Review

Erskine, Elliot¹  MacPhee, Cait E.²  Stanley-Wall, Nicola R.¹ 

[1] Univ Dundee, Div Mol Microbiol, Sch Life Sci, Dundee DD1 5EH, Scotland

[2] Univ Edinburgh, Sch Phys, James Clerk Maxwell Bldg,Kings Bldg,Mayfield Rd, Edinburgh EH9 3JZ, Midlothian, Scotland

关键词: functional amyloid fibers;    biofilm matrix;    curli;    TasA;    PSM;   

DOI  :  10.1016/j.jmb.2018.07.026

来源: Elsevier

【 摘 要 】

Biofilms are ubiquitous in the natural and man-made environment. They are defined as microbes that are encapsulated in an extracellular, self-produced, biofilm matrix. Growing evidence from the genetic and biochemical analysis of single species biofilms has linked the presence of fibrous proteins to a functional biofilm matrix. Some of these fibers have been described as functional amyloid or amyloid-like fibers. Here we provide an overview of the biophysical and biological data for a wide range of protein fibers found in the biofilm matrix of Gram-positive and Gram-negative bacteria. (C) 2018 The Authors. Published by Elsevier Ltd.

【 授权许可】

Free