Mechanistic Insights into the Role of Atg11 in Selective Autophagy

JOURNAL OF MOLECULAR BIOLOGY

卷:432

Review

Zientara-Rytter, Katarzyna¹  Subramani, Suresh¹ 

[1] Univ Calif San Diego, Div Biol Sci, Sect Mol Biol, La Jolla, CA 92093 USA

关键词: Atg11;    Atg17;    autophagosome;    membrane tethering;    scaffold protein;   

DOI  :  10.1016/j.jmb.2019.06.017

来源: Elsevier

【 摘 要 】

Macroautophagy (referred to hereafter as autophagy) is an intracellular degradation pathway in which the formation of a double-membrane vesicle called the autophagosome is a key event in the transport of multiple cytoplasmic cargo (e.g., proteins, protein aggregates, lipid droplets or organelles) to the vacuole (lysosome in mammals) for degradation and recycling. During this process, autophagosomes are formed de novo by membrane fusion events leading to phagophore formation initiated at the phagophore assembly site. In yeast, Atg11 and Atg17 function as protein scaffolds, essential for selective and non-selective types of autophagy, respectively. While Atg17 functions in non-selective autophagy are well-defined in the literature, less attention is concentrated on recent findings regarding the roles of Atg11 in selective autophagy. Here, we summarize current knowledge about the Atg11 scaffold protein and review recent findings in the context of its role in selective autophagy initiation and autophagosome formation. (C) 2019 Elsevier Ltd. All rights reserved.

【 授权许可】

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