The Role of miRNAs in Regulating Gene Expression Networks

JOURNAL OF MOLECULAR BIOLOGY

卷:425

Review

Gurtan, Allan M.¹  Sharp, Phillip A.^1,2 

[1] MIT, Inst Integrat Canc Res, Cambridge, MA 02139 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

关键词: network;    miRNA;    let-7;    Drosha;    Dicer;   

DOI  :  10.1016/j.jmb.2013.03.007

来源: Elsevier

【 摘 要 】

MicroRNAs (miRNAs) are key regulators of gene expression. They are conserved across species, expressed across cell types, and active against a large proportion of the transcriptome. The sequence-complementary mechanism of miRNA activity exploits combinatorial diversity, a property conducive to network-wide regulation of gene expression, and functional evidence supporting this hypothesized systems-level role has steadily begun to accumulate. The emerging models are exciting and will yield deep insight into the regulatory architecture of biology. However, because of the technical challenges facing the network-based study of miRNAs, many gaps remain. Here, we review mammalian miRNAs by describing recent advances in understanding their molecular activity and network-wide function. (c) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

Free