Polarized Organization of the Cytoskeleton: Regulation by Cell Polarity Proteins

JOURNAL OF MOLECULAR BIOLOGY

卷:430

Review

Raman, Renuka¹  Pinto, Clyde Savio¹  Sonawane, Mahendra¹ 

[1] Tata Inst Fundamental Res, Dept Biol Sci, Homi Bhabha Rd, Bombay 400005, Maharashtra, India

关键词: cell polarity;    actin cytoskeleton;    microtubules;    polarity proteins;    cytoskeletal organisation;   

DOI  :  10.1016/j.jmb.2018.06.028

来源: Elsevier

【 摘 要 】

Polarity is one of the fundamental properties displayed by living organisms. In metazoans, cell polarity governs developmental processes and plays an essential role during maintenance of forms of tissues as well as their functions. The mechanisms of establishment and maintenance of cell polarity have been investigated extensively in the last two decades. This has resulted in identification of core cell polarity modules that control anterior posterior, front rear and apical basal polarity across various cell types. Here, we review how these polarity modules interact closely with the cytoskeleton during establishment and maintenance of cytoskeletal polarity. We further suggest that reciprocal interactions between cell polarity modules and the cytoskeleton consolidate the initial weaker polarity, arising from an external cue, into a committed polarized system. (C) 2018 The Authors. Published by Elsevier Ltd.

【 授权许可】

Free