HIV-1 Replication Benefits from the RNA Epitranscriptomic Code

JOURNAL OF MOLECULAR BIOLOGY

卷:431

Review

Kong, Weili^1,3  Rivera-Serrano, Efrain E.²  Neidleman, Jason A.³  Zhu, Jian¹ 

[1] Ohio State Univ, Dept Pathol, Wexner Med Ctr, Columbus, OH 43210 USA

[2] Univ Calif Davis, Dept Microbiol & Mol Genet, Davis, CA 95616 USA

[3] Univ Calif San Francisco, Gladstone Inst Virol & Immunol, San Francisco, CA 94158 USA

关键词: HIV-1;    RNA methylation;    Writers;    Readers;   

DOI  :  10.1016/j.jmb.2019.09.021

来源: Elsevier

【 摘 要 】

The effects of RNA methylation on HIV-1 replication remain largely unknown. Recent studies have discovered new insights into the effect of 2'-O-methylation and 5-methylcytidine marks on the HIV-1 RNA genome. As so far, HIV-1 benefits from diverse RNA methylations through distinct mechanisms. In this review, we summarize the recent advances in this emerging field and discuss the role of RNA methylation writers and readers in HIV1 infection, which may help to find alternative strategies to control HIV-1 infection. (C) 2019 Elsevier Ltd. All rights reserved.

【 授权许可】

Free