Archaea: The Final Frontier of Chromatin

JOURNAL OF MOLECULAR BIOLOGY

卷:433

Review

Laursen, Shawn P.¹  Bowerman, Samuel²  Luger, Karolin^2,3 

[1] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80303 USA

[2] Univ Colorado, Dept Biochem, Boulder, CO 80309 USA

[3] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

关键词: chromatin;    protein DNA interactions;    archaea;    histones;    Alba;   

DOI  :  10.1016/j.jmb.2020.166791

来源: Elsevier

【 摘 要 】

The three domains of life employ various strategies to organize their genomes. Archaea utilize features similar to those found in both eukaryotic and bacterial chromatin to organize their DNA. In this review, we discuss the current state of research regarding the structure-function relationships of several archaeal chromatin proteins (histones, Alba, Cren7, and Sul7d). We address individual structures as well as inferred models for higher-order chromatin formation. Each protein introduces a unique phenotype to chromatin organization, and these structures are put into the context of in vivo and in vitro data. We close by discussing the present gaps in knowledge that are preventing further studies of the organization of archaeal chromatin, on both the organismal and domain level. (C) 2020 Elsevier Ltd. All rights reserved.

【 授权许可】

Free