The cutaneous microfibrillar apparatus contains latent transforming growth factor-β binding protein-1 (LTBP-1) and is a repository for latent TGF-β1

JOURNAL OF INVESTIGATIVE DERMATOLOGY

卷:111

Article

Raghunath, M ; Unsöld, C ; Kubitscheck, U ; Bruckner-Tuderman, L ; Peters, R ; Meuli, M

关键词: fibrillin;    keratinocyte autografts burns;    microfibrils;   

DOI  :  10.1046/j.1523-1747.1998.00339.x

来源: Elsevier

【 摘 要 】

The transforming growth factors-beta 1 and beta 2 (TGF-beta) stimulate synthesis of extracellular matrix proteins in vitro and appear upregulated in fibrotic conditions, in scar formation, and in wound healing. The extracellular matrix in turn might also act as a scavenger or repository for TGF-beta. We therefore studied the in situ distribution of latent TGF binding protein-1 (LTBP-1) and latent TGF-beta 1 on extracellular matrix elements of normal human skin and skin regenerating from cultured keratinocyte autografts, We localized both LTBP-1 and latent TGF-beta 1 to fibrillin-containing (elastic) microfibrils. Both LTBP-1 and latent TGF-beta 1 were already present during the earliest stages of the de novo formation of the microfibrillar apparatus, i.e., on fusiform, randomly oriented microfibrils that later coalesced to form the typical candelabra-like structures in the papillary dermis. We show herewith that LTBP-1 exerts a dual role as a component of fibrillin-microfibrils of the skin and in targeting latent TGF-beta 1 to the cutaneous microfibrillar apparatus. Thus, this major connective tissue structure does not only serve as a force bearing element and scaffold for elastin deposition in the dermis, but also as an important repository for latent TGF-beta in the skin.

【 授权许可】

Free