An alternative approach to depigmentation by soybean extracts via inhibition of the PAR-2 pathway

JOURNAL OF INVESTIGATIVE DERMATOLOGY

卷:116

Article

Paine, C ; Sharlow, E ; Liebel, F ; Eisinger, M ; Shapiro, S ; Seiberg, M

关键词: keratinocyte;    melanocyte;    skin lightening;    soymilk;    STI;   

DOI  :  10.1046/j.1523-1747.2001.01291.x

来源: Elsevier

【 摘 要 】

The protease-activated receptor 2, expressed on keratinocytes but not on melanocytes, has been ascribed functional importance in the regulation of pigmentation by phagocytosis of melanosomes. Inhibition of protease-activated receptor 2 activation by synthetic serine protease inhibitors requires keratinocyte-melanocyte contact and results in depigmentation of the dark skinned Yucatan swine, suggesting a new class of depigmenting mechanism and agents. We therefore examined natural agents that could exert their effect via the protease-activated receptor 2 pathway. Here we show that soymilk and the soybean-derived serine protease inhibitors soybean trypsin inhibitor and Bowman-Birk inhibitor inhibit protease-activated receptor 2 cleavage, affect cytoskeletal and cell. surface organization, and reduce keratinocyte phagocytosis. The depigmenting activity of these agents and their capability to prevent ultraviolet-induced pigmentation are demonstrated both in vitro and in vivo. These results imply that inhibition of the protease-activated receptor 2 pathway by soymilk may be used as a natural alternative to skin lightening.

【 授权许可】

Free