MODULATION OF CONTACT SENSITIVITY RESPONSES BY BACTERIAL SUPERANTIGEN

JOURNAL OF INVESTIGATIVE DERMATOLOGY

卷:105

Article

SALOGA, J ; ENK, AH ; BECKER, D ; MOHAMADZADEH, M ; SPIELES, S ; BELLINGHAUSEN, I ; LEUNG, DYM ; GELFAND, EW ; KNOP, J

关键词: CONTACT SENSITIVITY;    SUPERANTIGEN;    STAPHYLOCOCCAL ENTEROTOXIN B;    2,4-DINITROFLUORBENZENE;   

DOI  :  10.1111/1523-1747.ep12317503

来源: Elsevier

【 摘 要 】

Superantigens are potent modulators of the immune system, especially T cells. Therefore, we determined the influence of superantigens on the T-cell-mediated immune response, contact sensitivity, We chose the combination of staphylococcal enterotoxin B (SEE) as superantigen and 2,4-dinitrofluorbenzene (DNFB) as the contact sensitizer, because in BALB/c mice SEE reacts almost exclusively with V beta 8(+) T cells, and these cells are capable of transferring contact sensitivity to DNFB from sensitized donors to naive syngeneic recipients. Pretreatment with a single intradermal injection of 50 ng SEB 24 h before DNFB exposure at the same site on the lower abdomen enhanced the induction of contact sensitivity: its intradermal injection permitted sensitization with non-sensitizing concentrations of DNFB as assessed by ear swelling responses after challenge with DNFB, In contrast, pretreatment with repeated intradermal injections of 50 ng SEE every other day over at least 1 week inhibited the induction of contact sensitivity following sensitization, The enhancing effect of SEB may be explained by the creation of a proinflammatory milieu in the skin after a single intradermal injection of the bacterial toxin, whereas the inhibitory effect may be due to tolerization of V beta 8(+) T cells. The data indicate that products of skin-colonizing bacteria that can serve as superantigens are able to augment or inhibit the developement of contact sensitivity.

【 授权许可】

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