Systematic review of the empirical investigation of resources to support decision-making regarding BRCA1 and BRCA2 genetic testing in women with breast cancer

PATIENT EDUCATION AND COUNSELING

卷:101

Review

Grimmett, Chloe¹  Pickett, Karen²  Shepherd, Jonathan²  Welch, Karen²  Recio-Saucedo, Alejandra³  Streit, Elke²  Seers, Helen¹  Armstrong, Anne^4,5  Cutress, Ramsey I.^6,7  Evans, D. Gareth⁸  Copson, Ellen^6,7  Meiser, Bettina⁹  Eccles, Diana^6,7  Foster, Claire¹ 

[1] Univ Southampton, Fac Hlth Sci, Southampton, Hants, England

[2] Univ Southampton, Southampton Hlth Technol Assessments Ctr, Southampton, Hants, England

[3] Univ Southampton, Natl Inst Hlth Res NIHR Collaborat Appl Hlth Res, Southampton, Hants, England

[4] Univ Manchester, Christie Hosp NHS Fdn Trust, Manchester, Lancs, England

[5] Univ Manchester, Fac Biol Med & Hlth, Manchester, Lancs, England

[6] Univ Southampton, Somers Canc Res Bldg, Southampton, Hants, England

[7] Univ Hosp Southampton, Somers Canc Res Bldg, Southampton, Hants, England

[8] Univ Manchester, Div Evolut & Genom Sci, Ctr Genom Med, Manchester, Lancs, England

[9] Univ New South Wales, Fac Med, Kensington, NSW 2033, Australia

关键词: BRCA1;    BRCA2;    Breast cancer;    Decision aid;    Decision support;    Treatment-focused genetic testing;   

DOI  :  10.1016/j.pec.2017.11.016

来源: Elsevier

【 摘 要 】

Objective: Identify existing resources developed and/or evaluated empirically in the published literature designed to support women with breast cancer making decisions regarding genetic testing for BRCA1/2 mutations. Methods: Systematic review of seven electronic databases. Studies were included if they described or evaluated resources that were designed to support women with breast cancer in making a decision to have genetic counselling or testing for familial breast cancer. Outcome and process evaluations, using any type of study design, as well as articles reporting the development of decision aids, were eligible for inclusion. Results: Total of 9 publications, describing 6 resources were identified. Resources were effective at increasing knowledge or understanding of hereditary breast cancer. Satisfaction with resources was high. There was no evidence that any resource increased distress, worry or decisional conflict. Few resources included active functionalities for example, values-based exercises, to support decision-making. Conclusion: Tailored resources supporting decision-making may be helpful and valued by patients and increase knowledge of hereditary breast cancer, without causing additional distress. Practice implications: Clinicians should provide supportive written information to patients where it is available. However, there is a need for robustly developed decision tools to support decision-making around genetic testing in women with breast cancer. (C) 2017 Elsevier B.V. All rights reserved.

【 授权许可】

Free