Cancer patient knowledge about and behavioral intentions after germline genome sequencing

PATIENT EDUCATION AND COUNSELING

卷:105

Article

Napier, Christine E.¹  Davies, Grace²  Butow, Phyllis N.^2,3  Schlub, Timothy E.⁴  Best, Megan C.^2,5  Bartley, Nicci²  Juraskova, Ilona^2,3  Meiser, Bettina⁶  Tucker, Katherine M.^6,7  Biesecker, Barbara B.⁸  Thomas, David M.^1,9  Ballinger, Mandy L.^1,9 

[1] Garvan Inst Med Res, Canc Theme, Darlinghurst, NSW, Australia

[2] Univ Sydney, Sch Psychol, Psycho Oncol Cooperat Res Grp PoCoG, Sydney, NSW, Australia

[3] Univ Sydney, Sch Psychol, Ctr Med Psychol & Evidence Based Decis Making CeM, Sydney, NSW, Australia

[4] Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW, Australia

[5] Univ Notre Dame Australia, Sydney, NSW, Australia

[6] Univ New South Wales, Prince Wales Clin Sch, Sydney, NSW, Australia

[7] Prince Wales Hosp, Hereditary Canc Clin, Randwick, NSW, Australia

[8] RTI Int, Newborn Screening Eth & Disabil Studies, Washington, DC USA

[9] Univ New South Wales, St Vincents Clin Sch, Sydney, NSW, Australia

关键词: Genome sequencing;    Cancer;    Knowledge;    Behavior intention;    Correlates;   

DOI  :  10.1016/j.pec.2021.07.004

来源: Elsevier

【 摘 要 】

Objectives: Germline genome sequencing (GS) is becoming mainstream in cancer diagnosis and risk management. Identifying knowledge gaps and determinants of health behavior change intentions will enable effective targeting of educational and management strategies to translate genomic findings into improved cancer outcomes. Methods: Probands diagnosed with cancer of likely genetic origin that consented to but not yet undergone GS, and their biological relatives, completed a cross-sectional questionnaire assessing GS knowledge and hypothetical intention to change behaviors. Results: Probands (n = 348; 57% university educated) and relatives (n = 213; 38% university educated) had moderate GS knowledge levels, with greater knowledge associated with higher education. Both populations reported high behavioral change intentions, significantly associated with being female (p = 0.01) and greater perceived importance of GS (p < 0.001), and for probands: being from English-speaking households (p = 0.003), higher socio-economic status (p = 0.01) and greater self-efficacy (p = 0.02). Conclusions: Increasing GS knowledge will enable realistic participant expectations surrounding germline GS. Actual behavior change should be monitored to determine whether increased cancer risk knowledge results in altered cancer-related behavior and ultimately, cancer outcomes. Practice implications: Educational resources should target specific populations to ensure informed decision making and expectation management. Support tools facilitating and maintaining behavioral change may be needed to achieve improved cancer patient outcomes. (C) 2021 Published by Elsevier B.V.

【 授权许可】

Free