Diet, behavior and immunity across the lifespan

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:58

Article; Proceedings Paper

Hale, Matthew W.¹  Spencer, Sarah J.^2,3  Conti, Bruno⁴  Jasoni, Christine L.⁵  Kent, Stephen¹  Radler, Morgan E.¹  Reyes, Teresa M.⁶  Sominsky, Luba^2,3 

[1] La Trobe Univ, Sch Psychol Sci, Melbourne, Vic, Australia

[2] RMIT Univ, Sch Hlth Sci, Melbourne, Vic, Australia

[3] RMIT Univ, Hlth Innovat Res Inst, Melbourne, Vic, Australia

[4] Scripps Res Inst, La Jolla, CA 92037 USA

[5] Univ Otago, Dept Anat, Gravida Natl Ctr Growth & Dev, Ctr Neuroendocrinol, Dunedin, New Zealand

[6] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

关键词: Diet;    Nutrition;    Immune;    Inflammation;    Microglia;    Cytokine;    IL-18;    Obesity;    Calorie restriction;    Lipopolysaccharide;   

DOI  :  10.1016/j.neubiorev.2014.12.009

来源: Elsevier

【 摘 要 】

It is increasingly appreciated that perinatal events can set an organism on a life-long trajectory for either health or disease, resilience or risk. One early life variable that has proven critical for optimal development is the nutritional environment in which the organism develops. Extensive research has documented the effects of both undernutrition and overnutrition, with strong links evident for an increased risk for obesity and metabolic disorders, as well as adversemental health outcomes. Recent work has highlighted a critical role of the immune system, in linking diet with long term health and behavioral outcomes. The present review will summarize the recent literature regarding the interactions of diet, immunity, and behavior. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

Free