Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: A systematic review and meta-analysis

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:90

Review

Rensma, Sytze P.^1,2  van Sloten, Thomas T.^1,2  Launer, Lenore J.³  Stehouwer, Coen D. A.^1,2 

[1] Maastricht Univ, Med Ctr, CARIM Sch Cardiovasc Dis, POB 616, NL-6200 MD Maastricht, Netherlands

[2] Maastricht Univ, Med Ctr, Dept Internal Med, P Debyelaan 25, NL-6229 HX Maastricht, Netherlands

[3] NIA, Intramural Res Program, Lab Epidemiol & Populat Sci, NIH, 7201 Wisconsin Ave, Bethesda, MD 20892 USA

关键词: Cerebral small vessel disease;    White matter hyperintensities;    Lacunes;    Microbleeds;    Perivascular spaces;    Cerebral atrophy;    Stroke;    Dementia;    Depression;    Mortality;    Systematic review;    Meta-analysis;   

DOI  :  10.1016/j.neubiorev.2018.04.003

来源: Elsevier

【 摘 要 】

MRI features of cerebral small vessel disease (CSVD), i.e. white matter hyperintensities, lacunes, microbleeds, perivascular spaces, and cerebral atrophy, may be associated with clinical events, but the strength of these associations remains unclear. We conducted a systematic review and meta-analysis on the association between these features and incident ischaemic and haemorrhagic stroke, all-cause dementia and depression, and all-cause mortality. For the association with stroke, 36 studies were identified (number of individuals/events [n] = 38,432/4,136), for dementia 28 (n = 16,458/1,709), for depression nine (n = 9,538/1,746), and for mortality 28 (n = 23,031/2,558). Only two studies evaluated perivascular spaces; these results were not pooled. Pooled analyses showed that all other features were associated with all outcomes (hazard ratios ranged 1.22-2.72). Combinations of two features were more strongly associated with stroke than any individual feature. Individual features and combinations of CSVD features are strongly associated with incident ischaemic and haemorrhagic stroke, all-cause dementia and depression, and all-cause mortality. If these associations are causal, the strength of these associations suggests that a substantial burden of disease is attributable to CSVD.

【 授权许可】

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