Do NMDA-R antagonists re-create patterns of spontaneous gamma-band activity in schizophrenia? A systematic review and perspective

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:124

Review

Bianciardi, Bianca¹  Uhlhaas, Peter J.^1,2 

[1] Univ Glasgow, Inst Neurosci & Psychol, Glasgow, Lanark, Scotland

[2] Charite, Dept Child & Adolescent Psychiat, Augustenburger Pl 1, D-13353 Berlin, Germany

关键词: Spontaneous gamma-band activity;    Resting-state;    EEG;    MEG-recordings;    Schizophrenia;    Ketamine;    MK-801;    PCP;    E;    I imbalance;   

DOI  :  10.1016/j.neubiorev.2021.02.005

来源: Elsevier

【 摘 要 】

NMDA-R hypofunctioninig is a core pathophysiological mechanism in schizophrenia. However, it is unclear whether the physiological changes observed following NMDA-R antagonist administration are consistent with gamma-band alterations in schizophrenia. This systematic review examined the effects of NMDA-R antagonists on the amplitude of spontaneous gamma-band activity and functional connectivity obtained from preclinical (n = 24) and human (n = 9) studies and compared these data to resting-state EEG/MEG-measurements in schizophrenia patients (n = 27). Overall, the majority of preclinical and human studies observed increased gamma-band power following acute administration of NMDA-R antagonists. However, the direction of gamma-band power alterations in schizophrenia were inconsistent, which involved upregulation (n = 10), decreases (n = 7), and no changes (n = 8) in spectral power. Five out of 6 preclinical studies observed increased connectivit y , while in healthy controls receiving Ketamine and in schizophrenia patients the direction of connectivity results was also inconsistent. Accordingly, the effects of NMDA-R hypofunctioning on gamma-band oscillations are different than pathophysiological signatures observed in schizophrenia. The implications of these findings for current E/I balance models of schizophrenia are discussed.

【 授权许可】

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