NGF-dependent neurons and neurobiology of emotions and feelings: Lessons from congenital insensitivity to pain with anhidrosis

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:87

Article

Indo, Yasuhiro¹ 

[1] Kumamoto Univ Hosp, Dept Pediat, Chuou Ku, Honjo 1-1-1, Kumamoto 8608556, Japan

关键词: Allostasis;    Congenital insensitivity to pain with anhidrosis;    Emotion;    Feeling;    Homeostasis;    Inflammation;    Interoception;    Nerve growth factor (NGF);    NGF-dependent neurons;    NGF-dependent primary afferent neurons;    NTRK1 gene;    Receptor tyrosine kinase for NGF;    Stress;    Sympathetic postganglionic neurons;    TrkA receptor;   

DOI  :  10.1016/j.neubiorev.2018.01.013

来源: Elsevier

【 摘 要 】

NGF is a well-studied neurotrophic factor, and TrkA is a receptor tyrosine kinase for NGF. The NGF-TrkA system supports the survival and maintenance of NGF-dependent neurons during development. Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive genetic disorder due to loss-of-function mutations in the NTRK1 gene encoding TrkA. Individuals with CIPA lack NGF-dependent neurons, including NGF-dependent primary afferents and sympathetic postganglionic neurons, in otherwise intact systems. Thus, the pathophysiology of CIPA can provide intriguing findings to elucidate the unique functions that NGF-dependent neurons serve in humans, which might be difficult to evaluate in animal studies. Preceding studies have shown that the NGF-TrkA system plays critical roles in pain, itching and inflammation. This review focuses on the clinical and neurobiological aspects of CIPA and explains that NGF-dependent neurons in the peripheral nervous system play pivotal roles in interoception and homeostasis of our body, as well as in the stress response. Furthermore, these NGF-dependent neurons are likely requisite for neurobiological processes of 'emotions and feelings' in our species.

【 授权许可】

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