Common and distinct neural correlates of fear extinction and cognitive reappraisal: A meta-analysis of fMRI studies

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:104

Review

Pico-Perez, M.^1,2,3  Alemany-Navarro, M.^1,4  Dunsmoor, J. E.⁵  Radua, J.^6,7,8,9  Albajes-Eizagirre, A.^6,9  Vervliet, B.¹⁰  Cardoner, N.^11,12  Benet, O.¹³  Harrison, B. J.^14,15  Soriano-Mas, C.^1,9,16  Fullana, M. A.^9,17 

[1] Bellvitge Univ Hosp, Bellvitge Biomed Res Inst IDIBELL, Dept Psychiat, Feixa Llarga S-N, Barcelona 08907, Spain

[2] Univ Minho, Sch Med, Life & Hlth Sci Res Inst ICVS, Braga, Portugal

[3] ICVS 3Bs PT Govt Associate Lab, Braga, Portugal

[4] Univ Barcelona, Sch Med, Dept Clin Sci, Barcelona, Spain

[5] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA

[6] Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Spain

[7] Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res & Educ, Stockholm, Sweden

[8] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England

[9] Mental Hlth Res Networking Ctr CIBERSAM, Barcelona, Spain

[10] Univ KU Leuven, Fac Psychol & Educ Sci, Res Unit Brain & Cognit, Lab Biol Psychol, Leuven, Belgium

[11] Parc Tauli Univ Hosp, Adult Mental Hlth Unit, Sabadell, Spain

[12] Univ Autonoma Barcelona, Dept Psychiat & Forens Med, Barcelona, Spain

[13] Autonomous Univ Barcelona, Barcelona, Spain

[14] Univ Melbourne, Dept Psychiat, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia

[15] Melbourne Hlth, Melbourne, Vic, Australia

[16] Univ Autonoma Barcelona, Dept Psychobiol & Methodol Hlth Sci, Barcelona, Spain

[17] Hosp Clin Barcelona, Inst Neurosci, Rosello 140, Barcelona 08036, Spain

关键词: Emotion regulation;    Fear extinction;    Cognitive reappraisal;    Reinterpretation;    Distancing;    fMRI;    Meta-analysis;   

DOI  :  10.1016/j.neubiorev.2019.06.029

来源: Elsevier

【 摘 要 】

Cognitive reappraisal and fear extinction learning represent two different approaches to emotion regulation. While their respective neural correlates have been widely studied with functional magnetic resonance imaging (fMRI), few direct comparisons between these processes have been conducted. We conducted a meta-analysis of fMRI studies of reappraisal and fear extinction, with the aim of examining both commonalities and differences in their neural correlates. We also conducted independent analyses that focused on specific reappraisal strategies (reinterpretation, distancing). Overall, we observed that the dorsal anterior cingulate cortex (dACC) and the bilateral anterior insular cortex (AIC) were similarly consistently engaged by reappraisal and extinction. Extinction was more consistently linked to activation of sensory and emotion processing regions, whereas reappraisal was more consistently associated with activation of a dorsal fronto-parietal network. Interestingly, the amygdala was preferentially deactivated by distancing. These results suggest that the dACC and the AIC are involved in domain-general regulatory networks. Differences between extinction and reappraisal could be explained by their relative processing demands on visual perceptual versus higher cognitive neural systems.

【 授权许可】

Free