Is autonomic function during resting-state atypical in Autism: A systematic review of evidence

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:125

Review

Arora, Iti¹  Bellato, Alessio¹  Ropar, Danielle²  Hollis, Chris^1,3,4  Groom, Madeleine J.¹ 

[1] Univ Nottingham, Inst Mental Hlth, Sch Med, Div Psychiat & Appl Psychol, Innovation Pk,Triumph Rd, Nottingham NG7 2TU, England

[2] Univ Nottingham, Sch Psychol, Univ Pk, Nottingham NG7 2RD, England

[3] Univ Nottingham, Inst Mental Hlth, NIHR MindTech Healthcare Technol Cooperat, Nottingham NG7 2TU, England

[4] Inst Mental Hlth, NIHR Nottingham Biomed Res Ctr, Innovat Pk,Triumph Rd, Nottingham NG7 2TU, England

关键词: Autism spectrum disorder;    Autonomic arousal;    Resting State;    Heart rate variability;    Electrodermal activity;    Pupillometry;   

DOI  :  10.1016/j.neubiorev.2021.02.041

来源: Elsevier

【 摘 要 】

Background: Theories of differences in resting-state arousal in autistic individuals are influential. Differences in arousal during resting-state would impact engagement and adaptation to the environment, having a cascading effect on development of attentional and social skills. Objectives: We systematically evaluated the evidence for differences in measures of autonomic arousal (heart rate, pupillometry or electrodermal activity) during resting-state in autistic individuals; to understand whether certain contextual or methodological factors impact reports of such differences. Data sources: We searched PsycInfo, MEDLINE and EMBASE databases for papers published until 16th May 2019. Of 1207 titles initially identified, 60 met inclusion criteria. Results and Conclusions: Of the 51 studies that investigated group differences between neurotypical and autistic participants, 60.8 % found evidence of group differences. While findings of hyperarousal were more common, particularly using indices of parasympathetic function, findings of hypo-arousal and autonomic dysregulation were also consistently present. Importantly, experimental context played a role in revealing such differences. The evidence is discussed with regard to important methodological factors and implications for future research are described.

【 授权许可】

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