Circuits for social learning: A unified model and application to Autism Spectrum Disorder

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:107

Review

DeMayo, Marilena M.^1,3  Young, Larry J.²  Hickie, Ian B.^1,3  Song, Yun Ju C.^1,3  Guastella, Adam J.^1,3 

[1] Univ Sydney, Fac Med & Hlth, Childrens Hosp Westmead Clin Sch, Brain & Mind Ctr, Camperdown, NSW 2050, Australia

[2] Emory Univ, Silvio O Conte Ctr Oxytocin & Social Cognit, Dept Psychiat & Behav Sci, Yerkes Natl Primate Res Ctr,Ctr Translat Social N, Atlanta, GA 30322 USA

[3] Univ Sydney, Fac Med & Hlth, Cent Clin Sch, Brain & Mind Ctr, Camperdown, NSW 2050, Australia

关键词: Social development;    Social cognition;    Oxytocin;    Social skills training;    Neurodevelopment;    Amygdala;    Research domain criteria;    Infant;    Biomarkers;    Parent-child interaction;    Bonding;   

DOI  :  10.1016/j.neubiorev.2019.09.034

来源: Elsevier

【 摘 要 】

Early life social experiences shape neural pathways in infants to develop lifelong social skills. This review presents the first unified circuit-based model of social learning that can be applied to early life social development, drawing together unique human developmental milestones, sensitive learning periods, and behavioral and neural scaffolds. Circuit domains for social learning are identified governing Activation, Integration, Discrimination, Response and Reward (AIDRR) to sculpt and drive human social learning. This unified model can be used to identify social delays earlier in development. We propose social impairments observed in Autism Spectrum Disorder are underpinned by early mistimed sensitive periods in brain development and alterations in amygdala development to disrupt the AIDRR circuits. This model directs how interventions can target neural circuits for social development and be applied early in life. To illustrate, the role of oxytocin and its use as an intervention is explored. The AIDRR model shifts focus away from delivering broad treatments based only on diagnostic classifications, to specifying and targeting the relevant circuits, at the right time of development, to optimize social learning.

【 授权许可】

Free