Altered circadian profiles in attention-deficit/hyperactivity disorder: An integrative review and theoretical framework for future studies

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:36

Review

Imeraj, Lindita¹  Sonuga-Barke, Edmund J. S.^2,3  Antrop, Inge¹  Roeyers, Herbert³  Wiersema, Roeljan³  Bal, Sarah¹  Deboutte, Dirk^1,4,5 

[1] Ghent Univ Hosp, Dept Psychiat & Med Psychol, Child & Adolescent Psychiat Res Unit, B-9000 Ghent, Belgium

[2] Univ Southampton, Sch Psychol, Southampton SO17 1BJ, Hants, England

[3] Univ Ghent, Dept Expt Clin & Hlth Psychol, B-9000 Ghent, Belgium

[4] Univ Antwerp, B-2610 Antwerp, Belgium

[5] Univ Ctr Child & Adolescent Psychiat, B-2020 Antwerp, Belgium

关键词: ADHD;    Arousal;    Circadian;    Suprachiasmatic nucleus;    Eveningness;    Behavior;    Sleep;    Melatonin;    Cortisol;    Heart rate;    Locus coeruleus;   

DOI  :  10.1016/j.neubiorev.2012.04.007

来源: Elsevier

【 摘 要 】

Disruptions in the sleep-wake cycle and the circadian system have been found in a wide range of psychiatric disorders and are generally correlated with clinical severity and diminished quality of life. Emerging evidence suggests similar disturbances may be found in attention-deficit/hyperactivity disorder (ADHD). Here we review the available literature on across the day fluctuations in ADHD-related processes in terms of; (i) time of day effects on behavior and activity; (ii) morningness-eveningness chronotypology; (iii) sleep/wake rhythms; and (iv) rhythmicity in neuroendocrine and neurophysiological responsiveness. On this basis, we propose a neurobiological framework to guide future study, which sees circadian effects in ADHD, along with other aspects of ADHD arousal-related deficits (e.g., cognitive energetic deficits), as being the result of dysregulated locus coeruleus function. Based on this perspective specific recommendations for future research are presented. (C) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

Free