Progressive increase in the complexity and translatability of rodent testing to assess space-radiation induced cognitive impairment

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:126

Review

Britten, Richard A.^1,2,3,4  Wellman, Laurie L.^4,5  Sanford, Larry D.^4,5 

[1] Eastern Virginia Med Sch, Dept Radiat Oncol, 700 W Olney Rd,Lewis Hall, Norfolk, VA 23507 USA

[2] Eastern Virginia Med Sch, Dept Microbiol & Mol Cell Biol, Norfolk, VA 23507 USA

[3] Eastern Virginia Med Sch, Leroy T Canoles Jr Canc Ctr, Norfolk, VA 23507 USA

[4] Eastern Virginia Med Sch, Ctr Integrat Neurosci & Inflammatory Dis, Norfolk, VA 23507 USA

[5] Eastern Virginia Med Sch, Dept Pathol & Anat, Norfolk, VA 23507 USA

关键词: Space radiation;    Behavioral performance;    Executive functions;    Meta-cognition;    Stress;    Sleep;    Cognitive rehabilitation;    Cognitive flexibility;    Time perception;   

DOI  :  10.1016/j.neubiorev.2021.01.027

来源: Elsevier

【 摘 要 】

Ground-based rodent models have established that space radiation doses (approximately those that astronauts will be exposed to on a mission to Mars) significantly impair performance in a wide range of cognitive tasks. Over the last 40 years there has been a progressive increase in both the complexity and the translatability (to humans) of the cognitive tasks investigated. This review outlines technical and conceptual advances in space radiation rodent testing approaches, along with the advances in analytical approaches, that will make data from ground based studies more amenable to probabilistic risk analysis. While great progress has been made in determining the impact of space radiation on many advanced cognitive processes, challenges remain that need to be addressed prior to commencing deep space missions. A summary of on-going attempts to address existing knowledge gaps and the critical role that rodent studies will have in establishing the impact of space radiation on even more complex (human) cognitive tasks are presented and discussed.

【 授权许可】

Free