Linking cortical circuit models to human cognition with laminar fMRI

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:128

Article

Yang, Jiajia^1,2  Huber, Laurentius³  Yu, Yinghua^1,2  Bandettini, Peter A.^2,4 

[1] Okayama Univ, Grad Sch Interdisciplinary Sci & Engn Hlth Syst, Okayama, Japan

[2] NIMH, Sect Funct Imaging Methods, Bethesda, MD 20892 USA

[3] Univ Maastricht, Fac Psychol & Neurosci, MR Methods Grp, Maastricht, Netherlands

[4] NIMH, Funct MRI Core Facil, Bethesda, MD 20892 USA

关键词: Cortical layers;    Laminar fMRI;    Cortical circuit models;    Human brain function;    Cognition;   

DOI  :  10.1016/j.neubiorev.2021.07.005

来源: Elsevier

【 摘 要 】

Laboratory animal research has provided significant knowledge into the function of cortical circuits at the laminar level, which has yet to be fully leveraged towards insights about human brain function on a similar spatiotemporal scale. The use of functional magnetic resonance imaging (fMRI) in conjunction with neural models provides new opportunities to gain important insights from current knowledge. During the last five years, human studies have demonstrated the value of high-resolution fMRI to study laminar-specific activity in the human brain. This is mostly performed at ultra-high-field strengths (>= 7 T) and is known as laminar fMRI. Advancements in laminar fMRI are beginning to open new possibilities for studying questions in basic cognitive neuroscience. In this paper, we first review recent methodological advances in laminar fMRI and describe recent human laminar fMRI studies. Then, we discuss how the use of laminar fMRI can help bridge the gap between cortical circuit models and human cognition.

【 授权许可】

Free