The contribution of TMS-EEG coregistration in the exploration of the human cortical connectome

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:49

Review

Bortoletto, Marta¹  Veniero, Domenica²  Thut, Gregor²  Miniussi, Carlo^1,3 

[1] IRCCS Ctr San Giovanni Dio Fatebenefratelli, Cognit Neurosci Sect, I-25125 Brescia, Italy

[2] Univ Glasgow, Ctr Cognit Neuroimaging, Inst Neurosci & Psychol, Glasgow, Lanark, Scotland

[3] Univ Brescia, Neurosci Sect, Dept Clin & Expt Sci, Brescia, Italy

关键词: Effective connectivity;    Functional connectivity;    TMS-evoked potential TEP;    Graph theory;    Transcranial magnetic stimulation (TMS);    Electroencephalography (EEG);    Coregistration;    Connections;    Non-invasive brain stimulation (NIBS);   

DOI  :  10.1016/j.neubiorev.2014.12.014

来源: Elsevier

【 摘 要 】

Recent developments in neuroscience have emphasised the importance of integrated distributed networks of brain areas for successful cognitive functioning. Our current understanding is that the brain has a modular organisation in which segregated networks supporting specialised processing are linked through a few long-range connections, ensuring processing integration. Although such architecture is structurally stable, it appears to be flexible in its functioning, enabling long-range connections to regulate the information flow and facilitate communication among the relevant modules, depending on the contingent cognitive demands. Here we show how insights brought by the coregistration of transcranial magnetic stimulation and electroencephalography (TMS-EEG) integrate and support recent models of functional brain architecture. Moreover, we will highlight the types of data that can be obtained through TMS-EEG, such as the timing of signal propagation, the excitatory/inhibitory nature of connections and causality. Last, we will discuss recent emerging applications of TMS-EEG in the study of brain disorders. (C) 2014 The Authors. Published by Elsevier Ltd.

【 授权许可】

Free