Endometriosis and pain in the adolescent- striking early to limit suffering: A narrative review

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:108

Review

Sieberg, Christine B.^1,2,3,4  Lunde, Claire E.^1,2,5  Borsook, David^1,4 

[1] Boston Childrens Hosp, Ctr Pain & Brain, Dept Anesthesiol Crit Care & Pain Med, PAIN Grp, Boston, MA 02115 USA

[2] Boston Childrens Hosp, Dept Psychiat, Biobehav Pediat Pain Lab, Boston, MA 02115 USA

[3] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA

[4] Harvard Med Sch, Dept Anesthesiol, Boston, MA 02115 USA

[5] Univ Oxford, Nuffield Dept Womens & Reprod Hlth, Med Sci Div, Oxford, England

关键词: Endometriosis;    Chronic pelvic pain;    Inflammation;    Nerve;    Brain;    Psychology;    Treatment;    Adolescence;   

DOI  :  10.1016/j.neubiorev.2019.12.004

来源: Elsevier

【 摘 要 】

Endometriosis, a condition in which uterine tissue grows outside the uterus, is a debilitating disease, affecting millions of women and costing the United States approximately $78 billion annually in pain- related disability. It is also the leading cause of chronic pelvic pain (CPP), which is often unresponsive to existing treatments. Adolescent women with the disease are at particular risk as there are often significant diagnostic delays, which in turn can exacerbate pain. Research and treatment guidelines for adolescents with endometriosis are largely based on studies for adult women due to the limited number of studies focusing on adolescents. The current paper critically reviews the literature as it pertains to endometriosis pathophysiology, mechanisms contributing to CPP, and treatment implications and recommendations with a focus on gaps related to adolescents.

【 授权许可】

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