Brain areas associated with clinical and cognitive insight in psychotic disorders: A systematic review and meta-analysis

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:116

Review

Pijnenborg, G. H. M.^1,2  Larabi, D. I.^3,4,5,6  Xu, P.^7,8  Hasson-Ohayon, I.⁹  de Vos, A. E.¹  Curcic-Blake, B.³  Aleman, A.^1,3,6  Van der Meer, L.^10,11 

[1] GGZ Drenthe, Dept Psychot Disorders, Dennenweg 9, NL-9404 LA Assen, Netherlands

[2] Univ Groningen, Dept Clin & Dev Neuropsychol & Expt Psychopathol, Grote Kruisstr 2-1, NL-9712 TS Groningen, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Biomed Sci Cells & Syst, Cognit Neurosci Ctr, A Deusinglaan 2, NL-9713 AW Groningen, Netherlands

[4] Res Ctr Julich, Inst Neurosci & Med Brain & Behav INM 7, Julich, Germany

[5] Heinrich Heine Univ Dusseldorf, Inst Syst Neurosci, Med Fac, Dusseldorf, Germany

[6] Shenzhen Univ, Ctr Brain Disorders & Cognit Sci, Shenzhen Key Lab Affect & Social Neurosci, Shenzhen 518060, Peoples R China

[7] Shenzhen Inst Neurosci, Ctr Neuroimaging, Shenzhen 518054, Peoples R China

[8] Great Bay Neurosci & Technol Res Inst Hong Kong, Kwun Tong, Hong Kong, Peoples R China

[9] Bar Ilan Univ, Dept Psychol, IL-5290002 Ramat Gan, Israel

[10] Lentis Mental Hlth Care, Dept Rehabil, POB 128, NL-9470 KA Zuidlaren, Netherlands

[11] Univ Groningen, Dept Clin & Dev Neuropsychol, Grote Kruisstr 2-1, NL-9712 TS Groningen, Netherlands

关键词: Awareness;    Neuroimaging;    Psychosis;    Schizophrenia;    MRI;   

DOI  :  10.1016/j.neubiorev.2020.06.022

来源: Elsevier

【 摘 要 】

In the past years, ample interest in brain abnormalities related to clinical and cognitive insight in psychosis has contributed several neuroimaging studies to the literature. In the current study, published findings on the neural substrates of clinical and cognitive insight in psychosis are integrated by performing a systematic review and meta-analysis. Coordinate-based meta-analyses were performed with the parametric coordinate-based meta-analysis approach, non-coordinate based meta-analyses were conducted with the metafor package in R. Papers that could not be included in the meta-analyses were systematically reviewed. Thirty-seven studies were retrieved, of which 21 studies were included in meta-analyses. Poorer clinical insight was related to smaller whole brain gray and white matter volume and gray matter volume of the frontal gyri. Cognitive insight was predominantly positively associated with structure and function of the hippocampus and ventrolateral prefrontal cortex. Impaired clinical insight is not associated with abnormalities of isolated brain regions, but with spatially diffuse global and frontal abnormalities suggesting it might rely on a range of cognitive and self-evaluative processes. Cognitive insight is associated with specific areas and appears to rely more on retrieving and integrating self-related information.

【 授权许可】

Free