Role of BDNF and GDNF in drug reward and relapse: A review

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:35

Review

Ghitza, Udi E.³  Zhai, Haifeng²  Wu, Ping²  Airavaara, Mikko¹  Shaham, Yavin¹  Lu, Lin² 

[1] NIDA, Intramural Res Program, NIH, Baltimore, MD USA

[2] Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China

[3] NIDA, Ctr Clin Trials Network, NIH, Bethesda, MD 20892 USA

关键词: Addiction;    Alcohol;    Cocaine;    Craving;    Drug self-administration;    Extinction;    Heroin;    Incubation;    Mesocorticolimbic dopamine system;    Neuroadaptations;    Relapse;    Reinstatement;   

DOI  :  10.1016/j.neubiorev.2009.11.009

来源: Elsevier

【 摘 要 】

Brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) are neurotrophic factors that are critical for the growth, survival, and differentiation of developing neurons. These neurotrophic factors also play important roles in the survival and function of adult neurons, learning and memory, and synaptic plasticity. Since the mid-1990s, investigators have studied the role of BDNF and GDNF in the behavioral effects of abused drugs and in the neuroadaptations induced by repeated exposure to drugs in the mesocorticolimbic dopamine system. Here, we review rodent studies on the role of BDNF and GDNF in drug reward, as assessed in the drug self-administration and the conditioned place preference procedures, and in drug relapse, as assessed in extinction and reinstatement procedures. Our main conclusion is that whether BDNF or GDNF would facilitate or inhibit drug-taking behaviors depends on the drug type, the brain site, the addiction phase (initiation, maintenance, or abstinence/relapse), and the time interval between site-specific BDNF or GDNF injections and the reward- and relapse-related behavioral assessments. Published by Elsevier Ltd.

【 授权许可】

Free