Episodic and working memory function in Primary Progressive Aphasia: A meta-analysis

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:92

Review

Eikelboom, Willem S.¹  Janssen, Nikki^2,3  Jiskoot, Lize C.^1,4  van den Berg, Esther¹  Roelofs, Ardi²  Kessels, Roy P. C.^2,3,5 

[1] Erasmus MC, Dept Neurol, Rotterdam, Netherlands

[2] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Montessorilaan 3, NL-6525 HR Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Med Psychol, Njmegen, Netherlands

[4] Leiden Univ, Med Ctr, Dept Radiol, Leiden, Netherlands

[5] Vincent van Gogh Inst Psychiat, Venray, Netherlands

关键词: Primary progressive aphasia;    Progressive nonfluent aphasia;    Logopenic aphasia;    Semantic dementia;    Frontotemporal dementia;    Memory;    Systematic review;    Meta-analysis;   

DOI  :  10.1016/j.neubiorev.2018.06.015

来源: Elsevier

【 摘 要 】

Objective: The distinction between Primary Progressive Aphasia (PPA) variants remains challenging for clinicians, especially for the non-fluent (nfv-PPA) and the logopenic variants (lv-PPA). Previous research suggests that memory tests might aid this differentiation. This meta-analysis compares memory function among PPA variants. Method: Effects sizes were extracted from 41 studies (N = 849). Random-effects models were used to compare performance on episodic and working memory tests among PPA patients and healthy controls, and between the PPA variants. Results: Memory deficits were frequently observed in PPA compared to controls, with large effect sizes for lv-PPA (Hedges' g = -2.04 [-2.58 to -1.49]), nfv-PPA (Hedges' g = -1.26 ([-1.60 to -0.92], p <.001)), and the semantic variant (sv-PPA; Hedges' g = -1.23 [-1.50 to -0.97]). Sv-PPA showed primarily verbal memory deficits, whereas lv-PPA showed worse performance than nfv-PPA on both verbal and non-verbal memory tests. Conclusions: Memory deficits were more pronounced in lv-PPA compared to nfv-PPA. This suggests that memory tests may be helpful to distinguish between these PPA variants.

【 授权许可】

Free