The social nature of mitochondria: Implications for human health

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:120

Review

Picard, Martin^1,2,3  Sandi, Carmen⁴ 

[1] Columbia Univ, Dept Psychiat, Irving Med Ctr, Div Behav Med, New York, NY 10032 USA

[2] Columbia Univ, Dept Neurol, H Houston Merritt Ctr, Columbia Translat Neurosci Initiat,Irving Med Ctr, New York, NY USA

[3] New York State Psychiat Inst & Hosp, New York, NY 10032 USA

[4] Swiss Fed Inst Technol Lausanne EPFL, Brain Mind Inst, Lab Behav Genet, Lausanne, Switzerland

关键词: Social behavior;    Mitochondrial dynamics;    Networks;    Communication;    Interdisciplinary;    Psychobiology;    Biomarker;   

DOI  :  10.1016/j.neubiorev.2020.04.017

来源: Elsevier

【 摘 要 】

Sociality has profound evolutionary roots and is observed from unicellular organisms to multicellular animals. In line with the view that social principles apply across levels of biological complexity, a growing body of data highlights the remarkable social nature of mitochondria - life-sustaining endosymbiotic organelles with their own genome that populate the cell cytoplasm. Here, we draw from organizing principles of behavior in social organisms to reveal that similar to individuals among social networks, mitochondria communicate with each other and with the cell nucleus, exhibit group formation and interdependence, synchronize their behaviors, and functionally specialize to accomplish specific functions within the organism. Mitochondria are social organelles. The extension of social principles across levels of biological complexity is a theoretical shift that emphasizes the role of communication and interdependence in cell biology, physiology, and neuroscience. With the help of emerging computational methods capable of capturing complex dynamic behavioral patterns, the implementation of social concepts in mitochondrial biology may facilitate cross-talk across disciplines towards increasingly holistic and accurate models of human health.

【 授权许可】

Free