Perinatal selective serotonin reuptake inhibitor medication (SSRI) effects on social behaviors, neurodevelopment and the epigenome

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:85

Article; Proceedings Paper

Gemmel, Mary¹  Bogi, Eszter²  Ragan, Christina³  Hazlett, Mariah¹  Dubovicky, Michal²  van den Hove, Daniel L.^4,5  Oberlander, Tim F.^6,7  Charlier, Thierry D.⁸  Pawluski, Jodi L.⁸ 

[1] Ohio Univ, Dept Biol Sci, Athens, OH 45701 USA

[2] Slovak Acad Sci, Inst Expt Pharmacol & Toxicol, Bratislava, Slovakia

[3] Colgate Univ, Dept Psychol, Hamilton, NY 13346 USA

[4] Maastricht Univ, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

[5] Univ Wurzburg, Div Mol Psychiat, Ctr Mental Hlth, Lab Translat Neurosci, Wurzburg, Germany

[6] Univ British Columbia, Dept Pediat, BC Childrens Hosp, Res Inst, Vancouver, BC, Canada

[7] Univ British Columbia, Dept Pediat, BC Womens Hosp, BC Childrens Hosp,Res Inst, Vancouver, BC, Canada

[8] Univ Rennes 1, Res Inst Hlth Environm & Occupat, INSERM, U1085, Rennes, France

关键词: Maternal care;    Development;    Offspring;    Perinatal depression;    SSRI;    Pregnancy;    Stress;    Play behavior;    Social interaction;    Reproductive behavior;    Antidepressant;    Sex differences;    Serotonin;    Maternal stress;    Maternal anxiety;   

DOI  :  10.1016/j.neubiorev.2017.04.023

来源: Elsevier

【 摘 要 】

Recent research has linked early life exposure to selective serotonin reuptake inhibitor medications (SSRls) to modifications of social behaviors in children. Serotonin is a key regulator of neurodevelopment, social behaviors and mental health, and with the growing use of SSRIs to treat maternal affective disorders during the perinatal period, questions have been raised about the benefits and risks of perinatal SSRI exposure on the developing child. This review will highlight how perinatal SSRIs affect maternal care and neurodevelopmental outcomes related to social affiliative behaviors in offspring; such as play behaviors, social interactions, reproductive behaviors, and maternal care of the next generation. We will also review how early life exposure to SSRIs can alter related neurobiology, and the epigenome. Both clinical research and findings from animal models will be discussed. Understanding the impact of perinatal SSRIs on neurobehavioral outcomes will improve the health and well-being of subsequent generations.

【 授权许可】

Free