Social brain, social dysfunction and social withdrawal

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:97

Review

Porcelli, Stefano¹  Van der Wee, Nic²  van der Werff, Steven²  Aghajani, Moji¹¹  Glennon, Jeffrey C.⁴  van Heukelum, Sabrina⁴  Mogavero, Floriana⁴  Lobo, Antonio³  Olivera, Francisco Javier³  Lobo, Elena³  Posadas, Mar³  Dukart, Juergen⁵  Kozak, Rouba⁶  Arce, Estibaliz⁶  Ikram, Arfan⁷  Vorstman, Jacob⁸  Bilderbeck, Amy⁹  Saris, Ilja¹¹  Kas, Martien J.¹⁰  Serretti, Alessandro¹ 

[1] Univ Bologna, Dept Biomed & NeuroMotor Sci, Viale Carlo Pepoli 5, I-40123 Bologna, Italy

[2] Leiden Univ, Med Ctr, Dept Psychiat, Leiden Inst Brain & Cognit Psychiat Neuroimaging, Leiden, Netherlands

[3] Univ Zaragoza, IIS Aragon, CIBERSAM, Inst Salud Carlos III, Zaragoza, Spain

[4] Radboud Univ Nijmegen, Dept Cognit Neurosci, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands

[5] Roche Innovat Ctr Basel, Pharma Res Early Dev, F Hoffmann La Roche, Basel, Switzerland

[6] Pfizer Inc, Global Res & Dev, Neurosci Res Unit, New York, NY USA

[7] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[8] Univ Med Ctr Utrecht, Kinder En Jeugdpsychiat & Onderzoeker, Div Hersenen, Psychiat, Utrecht, Netherlands

[9] P1vital Ltd, Wallingford, Oxon, England

[10] Univ Groningen, Groningen Inst Evolutionary Life Sci, Groningen, Netherlands

[11] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands

关键词: Social withdrawal;    Neurobiology;    Social brain;    Social dysfunction;    Social impairments;    Social cognition;    Social functioning;    Schizophrenia;    Alzheimer's disease;    Major depression disorder;   

DOI  :  10.1016/j.neubiorev.2018.09.012

来源: Elsevier

【 摘 要 】

The human social brain is complex. Current knowledge fails to define the neurobiological processes underlying social behaviour involving the (patho-) physiological mechanisms that link system-level phenomena to the multiple hierarchies of brain function. Unfortunately, such a high complexity may also be associated with a high susceptibility to several pathogenic interventions. Consistently, social deficits sometimes represent the first signs of a number of neuropsychiatric disorders including schizophrenia (SCZ), Alzheimer's disease (AD) and major depressive disorder (MDD) which leads to a progressive social dysfunction. In the present review we summarize present knowledge linking neurobiological substrates sustaining social functioning, social dysfunction and social withdrawal in major psychiatric disorders. Interestingly, AD, SCZ, and MDD affect the social brain in similar ways. Thus, social dysfunction and its most evident clinical expression (i.e., social withdrawal) may represent an innovative transdiagnostic domain, with the potential of being an independent entity in terms of biological roots, with the perspective of targeted interventions.

【 授权许可】

Free