Association of atopic diseases and attention-deficit/hyperactivity disorder: A systematic review and meta-analyses

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:74

Review

van der Schans, Jurjen¹  Cicek, Rukiye¹  de Vries, Tjalling W.²  Hak, Eelko¹  Hoekstra, Pieter J.³ 

[1] Univ Groningen, Dept Pharm Pharmacoepidemiol & Pharmacoecon, Antonius Deusinglaan 1, NL-9713 AV Groningen, Netherlands

[2] Med Ctr Leeuwarden, Pediat, Henri Dunantweg 2, NL-8934 AD Leeuwarden, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Hanzepl 1, NL-9713 GZ Groningen, Netherlands

关键词: Atopy;    Attention-Deficit/Hyperactivity Disorder;    Allergy;    Asthma;    Rhinitis;    Eczema;   

DOI  :  10.1016/j.neubiorev.2017.01.011

来源: Elsevier

【 摘 要 】

Over the last decades, the hypothesis has been raised that an atopic response could lead to the development of attention-deficit/hyperactivity disorder (ADHD). This study systematically reviews the observational cross-sectional and longitudinal studies that assessed the association between atopic disorders including asthma, atopic eczema, allergic rhinitis, and ADHD in children and adolescents. For longitudinal studies, a weighted Mantel-Haenszel odds ratio of these associations was estimated. The majority of cross-sectional and longitudinal studies reported a statistically significant positive association. The meta-analysis of longitudinal studies revealed an overall weighted odds ratio for asthma of 1.34 (95% confidence interval [CI] 1.24-1.44), 1.32 (95% CI 1.20-1.45) for atopic eczema, and 1.52 (95% CI 1.43-1.63) for allergic rhinitis. Heterogeneity of study data was low (I-2: 0%, p = 0.46 and p = 0.64, respectively) for both studies examining asthma and eczema but substantial for rhinitis studies (I-2: 82%, p = 0.004). This current systematic review provides strong evidence that ADHD is associated with atopic diseases and that individuals have a 30% to 50% greater chance of developing ADHD compared to controls. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

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