Polygenic risk scores for genetic counseling in psychiatry: Lessons learned from other fields of medicine

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:121

Review

Eeltink, E.^1,3  Van der Horst, M. Z.^1,3,4  Zinkstok, J. R.¹  Aalfs, C. M.²  Luykx, J. J.^1,3,4 

[1] Univ Utrecht, Univ Med Ctr Utrecht, Dept Psychiat, UMC Utrecht Brain Ctr, Utrecht, Netherlands

[2] Univ Utrecht, Univ Med Ctr Utrecht, Dept Genet, UMC Utrecht Brain Ctr, Utrecht, Netherlands

[3] Univ Utrecht, Univ Med Ctr Utrecht, Dept Translat Neurosci, UMC Utrecht Brain Ctr, Utrecht, Netherlands

[4] GGNet Mental Hlth, Opin Outpatient Clin 2, Warnsveld, Netherlands

关键词: Polygenic risk score;    Genetic counseling;    Genetic testing;    Psychiatry;    Breast cancer;    Cardiovascular disease;    Alzheimer's disease;   

DOI  :  10.1016/j.neubiorev.2020.11.021

来源: Elsevier

【 摘 要 】

Polygenic risk scores (PRS) may aid in the identification of individuals at-risk for psychiatric disorders, treatment optimization, and increase in prognostic accuracy. PRS may also add significant value to genetic counseling. Thus far, integration of PRSs in genetic counseling sessions remains problematic because of uncertainties in risk prediction and other concerns. Here, we review the current utility of PRSs in the context of clinical psychiatry. By comprehensively appraising the literature in other fields of medicine including breast cancer, Alzheimer's Disease, and cardiovascular disease, we outline several lessons learned that could be applied to future studies and may thus benefit the incorporation of PRS in psychiatric genetic counseling. These include integrating PRS with environmental factors (e.g. lifestyle), setting up large-scale studies, and applying reproducible methods allowing for cross-validation between cohorts. We conclude that psychiatry may benefit from experiences in these fields. PRS may in future have a role in genetic counseling in clinical psychiatric practice, by advancing prevention strategies and treatment decision-making, thus promoting quality of life for (potentially) affected individuals.

【 授权许可】

Free