The link between maternal obesity and offspring neurobehavior: A systematic review of animal experiments

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:98

Review

Menting, Malou D.^1,2,3,4  de Beek, Cornelieke van^1,2,4  Mintjens, Stijn^1,2,5  Wever, Kimberley E.⁶  Korosi, Aniko⁷  Ozanne, Susan E.^8,9  Limpens, Jacqueline¹⁰  Roseboom, Tessa J.^1,2,3,4  Hooijman, Carlijn^6,11  Painter, Rebecca C.^1,2 

[1] Amsterdam UMC, Dept Obstet & Gynecol, Room H4-260,Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

[2] Amsterdam UMC, Amsterdam Reprod & Dev Res Inst, Amsterdam, Netherlands

[3] Amsterdam UMC, Dept Clin Epidemiol Biostat & Bioinformat, Amsterdam, Netherlands

[4] Amsterdam UMC, Dept Pediat, Amsterdam, Netherlands

[5] Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands

[6] Radboud Univ Nijmegen, Med Ctr, Dept Hlth Evidence Unit SYRCLE, Nijmegen, Netherlands

[7] Univ Amsterdam, Swammerdam Inst Life Sci, Amsterdam, Netherlands

[8] Univ Cambridge, Metab Res Labs, Cambridge, England

[9] Univ Cambridge, MRC Metab Dis Unit, Cambridge, England

[10] Amsterdam UMC, Dept Res Support, Med Lib, Amsterdam, Netherlands

[11] Radboud Univ Nijmegen, Med Ctr, Dept Anesthesiol, Nijmegen, Netherlands

关键词: Obesity;    Pregnancy;    Neurobehavior;    Offspring;    Animal experiments;    Systematic review;   

DOI  :  10.1016/j.neubiorev.2018.12.023

来源: Elsevier

【 摘 要 】

Maternal obesity in pregnancy is associated with neurobehavioral problems in the offspring. Establishing causality has been challenging in existing human studies, due to confounding by genetic and postnatal environment. Animal experiments can improve our understanding of this association. This systematic review examined the effects of maternal obesity in pregnancy on offspring neurobehavior in animal models. We included 26 studies (1047 offspring animals). Meta-analyses showed that offspring of obese mothers displayed higher levels of locomotor activity (standardized mean difference (SMD) 0.34 [0.10; 0.581) and anxiety behavior (SMD 0.47 [0.16; 0.79]) than offspring of lean mothers, but similar memory abilities (SMD - 0.06 [- 0.52; 0.39]). Meta-analysis of learning abilities was not sensible due to heterogeneity. Although the evidence was heterogeneous and the quality of the included studies generally unclear, this systematic review of animal studies indicates an effect of maternal obesity on increased offspring locomotor activity and anxiety, but not on offspring memory performance. These findings may be important from a public health perspective since obesity is rapidly increasing worldwide, and warrant further research.

【 授权许可】

Free